
Spastic paraplegia 50 (SPG50) is both a neurodevelopmental and a slowly progressive neurological disorder that generally presents with global developmental delay, moderate to severe intellectual disability, impaired/absent speech, small head size (microcephaly), seizures and progressive motor symptoms. Hypotonia (low-muscle tone) develops into hypertonia (high-muscle tone), resulting in spasticity of the legs that leads to non-ambulation and wheelchair reliance. Spasticity may progress to the upper extremities, leading to the partial or total loss of use of all four limbs and torso (tetraplegia).
​
Currently there are no active clinical trials active for this study but we hope to have more information soon on studies being developed around the world.
Terry Pirovolakis
Terry Pirovolakis
Terry Pirovolakis

Terry Pirovolakis
Clinical PI Team




Carsten Bönnemann
Carsten Bönnemann
Diane Balderson
Diane Balderson
Diane Balderson
Susan Iannaccone
Susan Iannaccone
Susan Iannaccone
Carsten Bönnemann
Tyler Pierson
Darius Ebrahimi-Fakhari
Steven Gray


Rotem Orbach
Rotem Orbach
Rotem Orbach
Rotem Orbach
Rotem Orbach
Joshua Todd
Partners
















