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Spastic paraplegia 50 (SPG50) is both a neurodevelopmental and a slowly progressive neurological disorder that generally presents with global developmental delay, moderate to severe intellectual disability, impaired/absent speech, small head size (microcephaly), seizures and progressive motor symptoms. Hypotonia (low-muscle tone) develops into hypertonia (high-muscle tone), resulting in spasticity of the legs that leads to non-ambulation and wheelchair reliance. Spasticity may progress to the upper extremities, leading to the partial or total loss of use of all four limbs and torso (tetraplegia).

Currently there are no active clinical trials active for this study but we hope to have more information soon on studies being developed around the world.

Terry Pirovolakis

Terry Pirovolakis

Terry Pirovolakis

Terry Pirovolakis

Clinical PI Team

Carsten Bönnemann

Carsten Bönnemann

Diane Balderson

Diane Balderson

Diane Balderson

Susan Iannaccone

Susan Iannaccone

Susan Iannaccone

Carsten Bönnemann

Tyler Pierson

Darius Ebrahimi-Fakhari 

Steven Gray

Rotem Orbach

Rotem Orbach

Rotem Orbach

Rotem Orbach

Rotem Orbach

Joshua Todd

Partners

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